CKAP5 and ARHGEF16

Number of citations of the paper that reports this interaction (PubMedID 30305138)
12

Data Source:
BioGRID (pull down)

		CKAP5	ARHGEF16
Description		cytoskeleton associated protein 5	Rho guanine nucleotide exchange factor 16
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GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end	Cytosol
	Molecular Function	Protein Binding Microtubule Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus-end Binding Microtubule Plus End Polymerase	Guanyl-nucleotide Exchange Factor Activity Protein Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Cadherin Binding
	Biological Process	Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation	Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Response to statin therapy ( 20339536)
Interacting Genes		11 interacting genes: ARHGEF16 AURKA CACNA1A CLASP1 CLK1 NDC80 PTPRN2 SLAIN2 SUMO2 TOP1 USP19	10 interacting genes: CKAP5 HNRNPH1 LASP1 LMNA LNX1 MAGED1 MAPK1IP1L TFG TNFRSF18 YWHAQ
Entrez ID		9793	27237
HPRD ID		10830	12478
Ensembl ID		ENSG00000175216	ENSG00000130762
Uniprot IDs		Q14008	B3KTS4 Q5VV41
PDB IDs		4QMI 4QMJ	1X6B
Enriched GO Terms of Interacting Partners?
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