RAPGEF5 and VANGL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		RAPGEF5	VANGL1
Description		Rap guanine nucleotide exchange factor 5	VANGL planar cell polarity protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body	Plasma Membrane Integral Component Of Membrane Lateral Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding	Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity	Pigmentation Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways			RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 34103634) Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Gamma glutamyl transferase levels ( 33339817) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)	Coronary artery disease ( 33020668) Gut microbiota (bacterial taxa) ( 27694959) Iron status biomarkers (ferritin levels) ( 33536631) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Optic disc size ( 31809533)
Interacting Genes		8 interacting genes: ITGB8 MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1	12 interacting genes: CD82 DVL1 DVL2 DVL3 FES GMFG LINC00839 NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2
Entrez ID		9771	81839
HPRD ID		15208	18279
Ensembl ID		ENSG00000136237	ENSG00000173218
Uniprot IDs		A8MQ07 Q5JPD2 Q92565	A0A024R0E3 Q8TAA9
PDB IDs		1WGY
Enriched GO Terms of Interacting Partners?
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