VANGL1 and RAPGEF5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		VANGL1	RAPGEF5
Description		VANGL planar cell polarity protein 1	Rap guanine nucleotide exchange factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Lateral Plasma Membrane	Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding
	Biological Process	Pigmentation Wnt Signaling Pathway, Planar Cell Polarity Pathway	Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Gut microbiota (bacterial taxa) ( 27694959) Iron status biomarkers (ferritin levels) ( 33536631) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Optic disc size ( 31809533)	Asthma ( 34103634) Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Gamma glutamyl transferase levels ( 33339817) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)
Interacting Genes		12 interacting genes: CD82 DVL1 DVL2 DVL3 FES GMFG LINC00839 NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2	8 interacting genes: ITGB8 MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		81839	9771
HPRD ID		18279	15208
Ensembl ID		ENSG00000173218	ENSG00000136237
Uniprot IDs		A0A024R0E3 Q8TAA9	A8MQ07 Q5JPD2 Q92565
PDB IDs			1WGY
Enriched GO Terms of Interacting Partners?
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