CEP57 and SPDEF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CEP57	SPDEF
Description		centrosomal protein 57	SAM pointed domain containing ETS transcription factor
Image
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Centrosome Cytosol Microtubule	Chromatin Nucleus
	Molecular Function	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity Gamma-tubulin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Microtubule Anchoring Protein Homooligomerization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 30423114 24390342) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Weight ( 28552196)
Interacting Genes		48 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 DISC1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OGT OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1	13 interacting genes: AR CEP57 COX5A ENKD1 ESR1 FAM161B NKX3-1 PCGF2 PSMA1 SNX20 SRPK2 STK11 TTC23
Entrez ID		9702	25803
HPRD ID		16261	12176
Ensembl ID		ENSG00000166037	ENSG00000124664
Uniprot IDs		Q86XR8	O95238
PDB IDs		4L0R	1YO5 2DKX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?