ESPL1 and PJA1

Number of citations of the paper that reports this interaction (PubMedID 22626734)
6

Data Source:
BioGRID (enzymatic study)

		ESPL1	PJA1
Description		extra spindle pole bodies like 1, separase	praja ring finger ubiquitin ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle	Cytoplasm
	Molecular Function	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Meiotic Chromosome Separation	Protein Ubiquitination Protein Catabolic Process
Pathways		Separation of Sister Chromatids	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		8 interacting genes: MTNR1B PJA1 RFFL TRAFD1 TRIM55 TRIM63 USP21 USP28	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		9700	64219
HPRD ID		06825	02335
Ensembl ID		ENSG00000135476	ENSG00000181191
Uniprot IDs		Q14674	Q8NG27
PDB IDs			2L0B
Enriched GO Terms of Interacting Partners?
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