ESPL1 and TRAFD1

		ESPL1	TRAFD1
Description		extra spindle pole bodies like 1, separase	TRAF-type zinc finger domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity	Protein Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Meiotic Chromosome Separation	Negative Regulation Of Innate Immune Response
Pathways		Separation of Sister Chromatids
Drugs
Diseases
GWAS		Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)	Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 26426971 25673413) Coffee consumption ( 29367735) Confectionary intake ( 33632354) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Spleen volume ( 34128465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: MTNR1B PJA1 RFFL TRAFD1 TRIM55 TRIM63 USP21 USP28	8 interacting genes: ESPL1 HTT KCNMB4 NGLY1 PRPF40B PTPRD TRAF6 UBC
Entrez ID		9700	10906
HPRD ID		06825	10994
Ensembl ID		ENSG00000135476	ENSG00000135148
Uniprot IDs		Q14674	A0A024RBK4 O14545
PDB IDs			2D9K
Enriched GO Terms of Interacting Partners?
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