PREX1 and NCDN

Number of citations of the paper that reports this interaction (PubMedID 26792863)
11

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		PREX1	NCDN
Description		phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	neurochondrin
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Dendritic Shaft Perinuclear Region Of Cytoplasm	Nucleus Cytosol Endosome Membrane Membrane Axon Dendrite Neuronal Cell Body Perikaryon Postsynapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding	Protein Binding
	Biological Process	Superoxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Neutrophil Activation Positive Regulation Of GTPase Activity Regulation Of Dendrite Development Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Neuron Projection Development Bone Resorption Regulation Of Neuronal Synaptic Plasticity
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Colorectal cancer ( 30529582 26151821 31826910) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Diastolic blood pressure ( 28135244 27841878 27618447) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Multiple myeloma ( 27363682) Nephrotic syndrome (acquired) ( 21441931) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Tonometry ( 17903302) Waist circumference ( 28552196) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: IPO13 ITSN1 MTOR NCDN PPP1CA RAC1 RHOA	14 interacting genes: A2M ACD EFHC2 KRT75 LCK LYST PAX6 POT1 PREX1 SEMA4C TINF2 TLE5 ZBED1 ZNF398
Entrez ID		57580	23154
HPRD ID		06066	10530
Ensembl ID		ENSG00000124126	ENSG00000020129
Uniprot IDs		Q8TCU6	Q9UBB6
PDB IDs		3QIK 4YON 5D27 5D3V 5D3W 5D3X 5D3Y 5FI0 5FI1 6PCV 6VSK
Enriched GO Terms of Interacting Partners?
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