FNIP1 and CUL2

Number of citations of the paper that reports this interaction (PubMedID 32941802)
6

Data Source:
BioGRID (enzymatic study)

		FNIP1	CUL2
Description		folliculin interacting protein 1	cullin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Cytosol	Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Enzyme Binding ATPase Inhibitor Activity Chaperone Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Immature B Cell Differentiation Positive Regulation Of B Cell Apoptotic Process Cellular Response To Starvation Positive Regulation Of Protein-containing Complex Assembly TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Pro-B Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway
Pathways		Amino acids regulate mTORC1	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Alzheimer's disease in APOE e4- carriers ( 25778476) Aspartate aminotransferase levels ( 34315874) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962) Ulcerative colitis ( 28067908)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		3 interacting genes: CUL2 HSP90AA1 PRKAA1	35 interacting genes: ABI1 ARID1B CAND1 CCND1 CDC34 CHD3 COMMD1 COPS5 CREM DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 FZD8 GJD4 GPS1 HSD17B7P2 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 UBE2D3 VHL ZER1 ZNF25 ZYG11B
Entrez ID		96459	8453
HPRD ID		17233	06786
Ensembl ID		ENSG00000217128	ENSG00000108094
Uniprot IDs		J3KNG8 Q8TF40	A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617
PDB IDs			4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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