CUL2 and FZD8

		CUL2	FZD8
Description		cullin 2	frizzled class receptor 8
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex	Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Neuron Differentiation Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation	Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Interacting Genes		35 interacting genes: ABI1 ARID1B CAND1 CCND1 CDC34 CHD3 COMMD1 COPS5 CREM DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 FZD8 GJD4 GPS1 HSD17B7P2 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 UBE2D3 VHL ZER1 ZNF25 ZYG11B	7 interacting genes: CUL2 GOPC LRP5 LRP6 RAE1 RYK WNT1
Entrez ID		8453	8325
HPRD ID		06786	05852
Ensembl ID		ENSG00000108094	ENSG00000177283
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617	Q9H461
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N	5UN5 5UN6 6NDZ
Enriched GO Terms of Interacting Partners?
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