ARHGEF10 and PINX1

		ARHGEF10	PINX1
Description		Rho guanine nucleotide exchange factor 10	PIN2 (TERF1) interacting telomerase inhibitor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol	Nuclear Chromosome Kinetochore Chromosome, Telomeric Region Nucleoplasm Nucleolus Mitochondrion Spindle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinesin Binding	Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding
	Biological Process	Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Centrosome Duplication Positive Regulation Of Stress Fiber Assembly Mitotic Spindle Assembly Activation Of GTPase Activity	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomeric DNA Binding Positive Regulation Of Protein Localization To Nucleolus
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Cleft lip with or without cleft palate x maternal periconceptional alcohol use interaction (parent of origin effect) ( 31372216) Delta-6 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) End-stage renal disease ( 29885931) HOMA-B (corrected for HOMA-IR) ( 30369944) Multiple sclerosis ( 23412934) Optic disc size ( 31809533) Toenail selenium levels ( 25343990)	Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder ( 30804558) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Retinal vascular caliber ( 21060863) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 24097068 30275531 20686565) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		5 interacting genes: CDC42 FHL3 PINX1 RAC1 RHOA	21 interacting genes: AIDA APP ARHGEF10 BNIP1 C14orf119 CACYBP DLGAP2 EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 PTP4A3 RP1L1 TERF1 TERT TLK1 TNPO2 TP63 UBL5
Entrez ID		9639	54984
HPRD ID		09735	05934
Ensembl ID		ENSG00000104728	ENSG00000254093
Uniprot IDs		O15013	Q96BK5
PDB IDs
Enriched GO Terms of Interacting Partners?
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