CD48 and IL18RAP

Number of citations of the paper that reports this interaction (PubMedID 15760905)
8

Data Source:
HPRD (in vivo)

		CD48	IL18RAP
Description		CD48 molecule	interleukin 18 receptor accessory protein
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Interleukin-18 Receptor Complex
	Molecular Function	Antigen Binding Protein Binding Signaling Receptor Activity	Protein Binding Interleukin-18 Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Regulation Of Adaptive Immune Response Defense Response T Cell Activation	Inflammatory Response Immune Response Cell Population Proliferation Interleukin-18-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide
Pathways		Cell surface interactions at the vascular wall	Interleukin-18 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 28240269) Celiac disease ( 22057235 20190752 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Extranodal natural killer T-cell lymphoma (nasal type) ( 31879220) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Systemic lupus erythematosus ( 28714469)
Interacting Genes		20 interacting genes: ACKR1 BRIX1 C1orf68 CD2 CD244 CD247 DIO1 E2F2 EEF1D EFNA1 EFNA3 FYN GNAI3 IL18R1 IL18RAP LCK LY9 MAST2 OAZ3 P4HA1	5 interacting genes: AFF3 APP CD48 IL18 TRIM54
Entrez ID		962	8807
HPRD ID		00177	05147
Ensembl ID		ENSG00000117091	ENSG00000115607
Uniprot IDs		A0A087X1S7 P09326	O95256
PDB IDs		2EDO	3WO4 6KN9
Enriched GO Terms of Interacting Partners?
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