NCOR1 and SKIL

Number of citations of the paper that reports this interaction (PubMedID 15231748)
99

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		NCOR1	SKIL
Description		nuclear receptor corepressor 1	SKI like proto-oncogene
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytosol Membrane Transcription Repressor Complex Mitotic Spindle	Acrosomal Vesicle Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Histone Deacetylase Binding Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Lymphocyte Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Response To Cytokine Negative Regulation Of Cell Differentiation Positive Regulation Of Axonogenesis Regulation Of Cell Cycle Lens Fiber Cell Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 Heme signaling Heme signaling	Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Adult body size ( 32376654) C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494)	Aspartate aminotransferase levels ( 33547301) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Prostate cancer ( 21743467)
Interacting Genes		90 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ENO1 ESR1 ESR2 ETS1 ETS2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 PDCD2 PHB PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA RAI1 RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 SUMO2 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TULP3 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB7A ZMYND11	96 interacting genes: ASCC3 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DEUP1 DHX30 DRG1 EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GAS8 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 HNRNPLL IL36RN KRT81 LRP1 MACF1 MORC4 MVP MYG1 NCOR1 NCOR2 NEFL NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMUG1 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TLE5 TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XPA XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1
Entrez ID		9611	6498
HPRD ID		02911	01319
Ensembl ID		ENSG00000141027	ENSG00000136603
Uniprot IDs		A0A024RD47 O75376 Q6PGR4	P12757
PDB IDs		2EQR 3H52 3KMZ 3N00 4MDD 4WVD 6ONI 6WMQ 6XXS 6XYX 6XZZ 6Y17 6ZBU	3EQ5 5C4V
Enriched GO Terms of Interacting Partners?
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