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NCOR1 and PDCD2
Number of citations of the paper that reports this interaction (PubMedID
12149646
)
21
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
NCOR1
PDCD2
Description
nuclear receptor corepressor 1
programmed cell death 2
Image
No pdb structure
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Membrane
Transcription Repressor Complex
Mitotic Spindle
Nucleus
Cytoplasm
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
Transcription Corepressor Activity
Protein Binding
Nuclear Receptor Binding
Histone Deacetylase Binding
Thyroid Hormone Receptor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA Binding
Protein Binding
Enzyme Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Locomotor Rhythm
Negative Regulation Of Glycolytic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Fatty Acid Metabolic Process
Negative Regulation Of JNK Cascade
Spindle Assembly
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of Hematopoietic Progenitor Cell Differentiation
Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways
Nuclear signaling by ERBB4
Nuclear signaling by ERBB4
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Transcriptional activation of mitochondrial biogenesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Circadian Clock
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Loss of MECP2 binding ability to the NCoR/SMRT complex
Regulation of MECP2 expression and activity
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Cytoprotection by HMOX1
Heme signaling
Heme signaling
Drugs
Diseases
GWAS
Adult body size (
32376654
)
C-reactive protein levels (
30388399
)
FEV1 (
30804560
)
Free thyroxine concentration (
30367059
)
Lung function (FEV1) (
26635082
)
Lung function (FVC) (
30804560
)
Lymphocyte counts (
32888494
)
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Interacting Genes
90 interacting genes:
ACTN2
AR
ATXN1
ATXN1L
ATXN3
BCL6
C1D
CBFA2T2
CHD1
CHUK
CLK1
CNOT2
COPS2
CSNK2A1
CXADR
DACH1
DDX20
DHX30
DZIP3
ENO1
ESR1
ESR2
ETS1
ETS2
GPS2
GTF2B
H3C1
H4C1
HDAC3
HDAC5
HDAC9
HESX1
HEY2
HTT
KLF5
MECP2
MYB
MYBL2
MYOD1
NCOA1
NCOA3
NCOR2
NELFE
NR1D1
NR1D2
NR1H2
NR1H3
NR2E3
NR3C1
NR6A1
PDCD2
PHB
PIAS1
PML
POU1F1
PPARA
PPARD
PPARG
PTMA
RAI1
RARA
RARG
RBPJ
RUNX1
RUNX1T1
RXRA
SAFB
SAP30
SKI
SKIL
SNW1
SP1
SPEN
SQSTM1
SUMO2
TAB2
TAF6
TAF9
TBL1X
TBL1XR1
THRA
THRB
TRIM14
TULP3
TXNRD2
VDR
ZBTB16
ZBTB33
ZBTB7A
ZMYND11
7 interacting genes:
ERRFI1
HCFC1
LSM8
NCOR1
NFKBIB
PRKN
TBC1D21
Entrez ID
9611
5134
HPRD ID
02911
02922
Ensembl ID
ENSG00000141027
ENSG00000071994
Uniprot IDs
A0A024RD47
O75376
Q6PGR4
A0A087WYJ3
Q16342
PDB IDs
2EQR
3H52
3KMZ
3N00
4MDD
4WVD
6ONI
6WMQ
6XXS
6XYX
6XZZ
6Y17
6ZBU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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