KIF23 and LATS2

Number of citations of the paper that reports this interaction (PubMedID 25658096)
4

Data Source:
BioGRID (enzymatic study)

		KIF23	LATS2
Description		kinesin family member 23	large tumor suppressor kinase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Focal Adhesion Midbody Mitotic Spindle Flemming Body Centralspindlin Complex	Spindle Pole Nucleus Cytosol Centriolar Satellite
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Spindle Elongation Mitotic Cytokinesis Microtubule-based Movement Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Mitotic Telophase/Cytokinesis Kinesins	Signaling by Hippo
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Rheumatoid arthritis (ACPA-positive) ( 24532676)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: ACTA1 ARF3 CLK1 LATS2 NMB PLK1 PPP1CB RACGAP1 RBM34 SUMO2 USP8 YWHAB YWHAG YWHAQ	68 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FLT1 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NF2 NFIC PDGFRA RAF1 RASSF1 RELA SMAD2 SNAI1 STK11 STK3 SUZ12 TAFAZZIN TEAD2 TP53 TSC1 WWTR1 YWHAG YWHAZ
Entrez ID		9493	26524
HPRD ID		05455	07277
Ensembl ID		ENSG00000137807	ENSG00000150457
Uniprot IDs		Q02241	A0A024RDM3 Q9NRM7
PDB IDs		3VHX	4ZRI
Enriched GO Terms of Interacting Partners?
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