LATS2 and SUZ12

Number of citations of the paper that reports this interaction (PubMedID 27434182)
5

Data Source:
BioGRID (enzymatic study)

		LATS2	SUZ12
Description		large tumor suppressor kinase 2	SUZ12 polycomb repressive complex 2 subunit
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytosol Centriolar Satellite	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Transcription Corepressor Binding Protein Binding Enzyme Activator Activity Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Catalytic Activity Histone H3-K27 Trimethylation
Pathways		Signaling by Hippo	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278)	High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		68 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FLT1 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NF2 NFIC PDGFRA RAF1 RASSF1 RELA SMAD2 SNAI1 STK11 STK3 SUZ12 TAFAZZIN TEAD2 TP53 TSC1 WWTR1 YWHAG YWHAZ	25 interacting genes: AEBP2 ARHGAP5 BCL11A CDK19 CDK5R1 CDK8 CREB1 EZH2 H1-1 H3-4 KLRC1 LATS2 MED17 MED6 NOL4 NR1D1 PAXIP1 PJA1 PLA2G2A PRDM14 RBBP4 SLC2A2 TBC1D29P UBE2I WDR77
Entrez ID		26524	23512
HPRD ID		07277	06949
Ensembl ID		ENSG00000150457	ENSG00000178691
Uniprot IDs		A0A024RDM3 Q9NRM7	J3QQW9 Q15022
PDB IDs		4ZRI	4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?