MED23 and CLCN3

		MED23	CLCN3
Description		mediator complex subunit 23	chloride voltage-gated channel 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Regulator Complex Mediator Complex	Golgi Membrane Lysosomal Membrane Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Integral Component Of Membrane Secretory Granule Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Intracellular Membrane-bounded Organelle Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Protein Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Antiporter Activity Solute:proton Antiporter Activity PDZ Domain Binding Volume-sensitive Chloride Channel Activity
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated	Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Stimuli-sensing channels
Drugs
Diseases
GWAS		L-arginine levels ( 25245031) Type 2 diabetes ( 30054458)	Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 25056061 29483656 30285260)
Interacting Genes		16 interacting genes: CEBPB CLCN3 CTDP1 ELF3 ESR1 ESR2 ETS1 FOXJ3 MED13 MED9 NCOA6 PUM2 RELA SREBF1 VDR WDTC1	17 interacting genes: ANXA10 CFTR DECR1 DNAJC5 ETFDH FZD3 GOPC GPRC5C GRIA2 HPF1 HSPB1 MED23 NEK1 PDGFB PDZK1 SLC9A3R1 VPS18
Entrez ID		9439	1182
HPRD ID		05436	02785
Ensembl ID		ENSG00000112282	ENSG00000109572
Uniprot IDs		Q05DL5 Q9ULK4	B3KXK0 P51790
PDB IDs		6H02
Enriched GO Terms of Interacting Partners?
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