COX5A and HTRA1

Number of citations of the paper that reports this interaction (PubMedID 15101818)
29

Data Source:
HPRD (two hybrid)

		COX5A	HTRA1
Description		cytochrome c oxidase subunit 5A	HtrA serine peptidase 1
Image
GO Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex IV	Extracellular Region Extracellular Space Cytosol Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Metal Ion Binding	Serine-type Endopeptidase Activity Protein Binding Insulin-like Growth Factor Binding Serine-type Peptidase Activity Identical Protein Binding
	Biological Process	Mitochondrial Electron Transport, Cytochrome C To Oxygen Proton Transmembrane Transport	Placenta Development Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Chorionic Trophoblast Cell Differentiation Dentinogenesis
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1	Degradation of the extracellular matrix
Drugs		Cholic Acid N-Formylmethionine
Diseases
GWAS		Caffeine consumption ( 21490707) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23326517 32741009 23455636 23536807 20861866 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 29212778 33020668) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30061609 30804560) Migraine ( 27322543) Myocardial infarction ( 33532862) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Stroke ( 29531354) Systolic blood pressure ( 30224653 30578418) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		10 interacting genes: COPS6 CYP1A1 EPM2A EXOSC8 HTRA1 KRT31 KRT40 MESD MT-CO1 SPDEF	22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP
Entrez ID		9377	5654
HPRD ID		04799	03725
Ensembl ID		ENSG00000178741	ENSG00000166033
Uniprot IDs		P20674	Q92743
PDB IDs		5Z62	2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?