UBE4A and IP6K1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		UBE4A	IP6K1
Description		ubiquitination factor E4A	inositol hexakisphosphate kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity	Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Inositol Heptakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Inositol Hexakisphosphate 1-kinase Activity Inositol Hexakisphosphate 3-kinase Activity Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Inositol Diphosphate Tetrakisphosphate Kinase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway	Phosphorylation Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Negative Regulation Of Cold-induced Thermogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of pyrophosphates in the cytosol Synthesis of IPs in the nucleus
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)	Blood protein levels ( 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hand grip strength ( 29691431) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip index ( 34021172) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Resting heart rate ( 29769521 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Ulcerative colitis ( 25082827) Visceral adipose tissue volume ( 34128465)
Interacting Genes		14 interacting genes: CASP6 EPHA2 GZMB IP6K1 MAVS PTTG1 RSAD2 SC5D SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP	12 interacting genes: ADAMTSL4 CACNA1A CLK1 COPS2 DDB1 EXOSC7 GPS1 PICK1 RAB3IL1 RPL11 UBE4A VIM
Entrez ID		9354	9807
HPRD ID		06793	07379
Ensembl ID		ENSG00000110344	ENSG00000176095
Uniprot IDs		Q14139	A0A024R2X2 Q92551
PDB IDs		1WGM
Enriched GO Terms of Interacting Partners?
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