UBE4A and RSAD2

Number of citations of the paper that reports this interaction (PubMedID 31812350)
8

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		UBE4A	RSAD2
Description		ubiquitination factor E4A	radical S-adenosyl methionine domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Fibrillar Center Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity	Protein Binding Lyase Activity Protein Self-association Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway	Response To Virus Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Virus Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)
Interacting Genes		14 interacting genes: CASP6 EPHA2 GZMB IP6K1 MAVS PTTG1 RSAD2 SC5D SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP	5 interacting genes: APOC1 APOC2 APOC4 RHBDD2 UBE4A
Entrez ID		9354	91543
HPRD ID		06793	07423
Ensembl ID		ENSG00000110344	ENSG00000134321
Uniprot IDs		Q14139	Q8WXG1
PDB IDs		1WGM
Enriched GO Terms of Interacting Partners?
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