SLC9A3R2 and P2RY1

Number of citations of the paper that reports this interaction (PubMedID 9671706)
105

Data Source:
HPRD (in vitro)

		SLC9A3R2	P2RY1
Description		SLC9A3 regulator 2	purinergic receptor P2Y1
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Exosome	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Postsynaptic Density Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Cell Body Postsynaptic Membrane Glutamatergic Synapse Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding	G Protein-coupled ADP Receptor Activity Protein Binding ATP Binding A1 Adenosine Receptor Binding Signaling Receptor Activity ADP Binding G Protein-coupled Purinergic Nucleotide Receptor Activity G Protein-coupled ATP Receptor Activity Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Protein-containing Complex Assembly Protein Localization To Plasma Membrane	Positive Regulation Of Protein Phosphorylation G Protein-coupled Adenosine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Aging Glial Cell Migration Regulation Of Cell Shape Response To Mechanical Stimulus Regulation Of Signaling Receptor Activity Negative Regulation Of Norepinephrine Secretion Sensory Perception Of Pain Signal Transduction Involved In Regulation Of Gene Expression Platelet Activation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Eating Behavior Positive Regulation Of Ion Transport Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Negative Regulation Of Binding Positive Regulation Of Penile Erection Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To ATP Cellular Response To Purine-containing Compound Protein Localization To Plasma Membrane Relaxation Of Muscle Blood Vessel Diameter Maintenance Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways			G alpha (q) signalling events P2Y receptors ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1
Drugs			Promethazine
Diseases
GWAS		Diastolic blood pressure ( 27841878 30578418) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Systolic blood pressure ( 27841878 30578418)	Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Chronotype ( 30696823) Immune reponse to smallpox (secreted IL-2) ( 22610502) Metabolite levels ( 23823483) Serum sulfate level ( 27412988)
Interacting Genes		43 interacting genes: ABCC4 ACE2 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR DLGAP4 EZR IFT140 KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TRAF4 WWP2 WWTR1	4 interacting genes: ADORA1 JAK1 SLC9A3R1 SLC9A3R2
Entrez ID		9351	5028
HPRD ID		05946	03103
Ensembl ID		ENSG00000065054	ENSG00000169860
Uniprot IDs		Q15599	P47900
PDB IDs		2D11 2HE4 2OCS 4P0C	1Y36 4XNV 4XNW
Enriched GO Terms of Interacting Partners?
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