SYCE1 and TPM1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		SYCE1	TPM1
Description		synaptonemal complex central element protein 1	tropomyosin 1
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Central Element Nucleoplasm Chromosome Cytosol Intracellular Membrane-bounded Organelle	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane
	Molecular Function	Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Synaptonemal Complex Assembly Cell Division	Positive Regulation Of Heart Rate By Epinephrine Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Meiotic synapsis	Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Artenimol Phenethyl Isothiocyanate
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 19820697 32888494 27863252) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 32888494 27863252) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		49 interacting genes: ALOX5 ARNT2 BEX2 BFSP2 CBY2 CCDC102B CCHCR1 CFAP100 CINP CNN1 CYTH3 EDRF1 EXOC8 FAM161A FAM161B HAUS1 HMG20B HOOK1 HSPB1 HSPB7 IQUB KAT5 KIFC3 KRT18 LMNA MBD3 MPV17 MRFAP1L1 NME7 PSTPIP1 RALBP1 RBCK1 RUNX1T1 SCNM1 SKA1 SMARCE1 SPATC1L SSX2 STX19 TFIP11 TPM1 TPM3 TRAF1 TRIM41 TSG101 TXN2 VPS25 WASHC3 ZNF124	33 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCDC96 CCHCR1 CDC42 CLIP4 EGFR EPB41 FAM9C FGA GOLGA2 IFIT3 JUN KXD1 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4 WASHC1 YEATS4
Entrez ID		93426	7168
HPRD ID		12598	01839
Ensembl ID		ENSG00000171772	ENSG00000140416
Uniprot IDs		A0A0B4J1R9 Q8N0S2	A0A024R5W6 A0A0K0K1I0 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H7BYY1 O15513 P09493
PDB IDs			3MUD 5KHT 6UT2 6X5Z
Enriched GO Terms of Interacting Partners?
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