TIFA and GSDME

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TIFA	GSDME
Description		TRAF interacting protein with forkhead associated domain	gasdermin E
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cardiolipin Binding
	Biological Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Protein Homooligomerization	Sensory Perception Of Sound Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Inner Ear Receptor Cell Differentiation Necrotic Cell Death Pyroptosis Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Alpha-protein kinase 1 signaling pathway	Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis
Drugs
Diseases
GWAS		Body mass index ( 26426971) Rheumatoid arthritis ( 30891314)
Interacting Genes		23 interacting genes: AP1M1 ARHGEF39 DVL2 GSDME IRAK1 KANK2 LNX1 LNX2 NIF3L1 NTAQ1 NUDT18 NXF1 PRKAA2 RIPPLY3 RPL9 SDCBP SDCBP2 TIFAB TNFAIP8 TRAF1 TRAF2 TRAF6 TXN2	11 interacting genes: AHR C1GALT1 GARS1 GP1BB GPNMB HNRNPA2B1 ITGB1BP1 PTN TBX19 TIFA VPS41
Entrez ID		92610	1687
HPRD ID		09835	02996
Ensembl ID		ENSG00000145365	ENSG00000105928
Uniprot IDs		Q96CG3	A0A024RA58 A4FVA8 O60443
PDB IDs		4YM4 4ZGI 5ZUJ 6A33
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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