DDX21 and KPNA3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		DDX21	KPNA3
Description		DExD-box helicase 21	karyopherin subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Mitochondrion Cytosol Membrane	Nucleus Nuclear Pore Nucleoplasm Cytosol Host Cell
	Molecular Function	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding	Protein Binding Protein C-terminus Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Defense Response To Virus R-loop Disassembly	NLS-bearing Protein Import Into Nucleus Viral Entry Into Host Cell Protein-containing Complex Assembly Viral Penetration Into Host Nucleus
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triiodothyronine/thyroxine ratio ( 30824882)
Interacting Genes		92 interacting genes: ADAMTS14 CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN KPNA3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MTHFR PIAS1 PNMA2 PTEN SGPL1 SRPK2 SUMO2 TERF1 TERF2 TET1 UBE2I	54 interacting genes: ANKRD11 APOL6 ARNT BAHD1 BRD3 CCDC102B CDKN1B COIL CYHR1 DDX21 EPAS1 EPHA2 ERCC3 ESR2 FAM214B FAM50B FAM90A1 FTL GATA6 GRB10 GTF2H1 GTF2IRD1 HEXIM2 HIF1A HNRNPC HSPB1 KAT5 KPNB1 L3MBTL4 MAPK9 MAT2B MVP MYOD1 NFE2L2 NFKB1 NMNAT1 OGT POLR3C RAD52 RBBP4 RCC1 RPRD1A SLC5A11 TEX37 TGM2 TNIP3 TSSC4 UVSSA ZBTB24 ZCCHC10 ZCCHC12 ZNF131 ZNF76 ZNF764
Entrez ID		9188	3839
HPRD ID		05895	03536
Ensembl ID		ENSG00000165732	ENSG00000102753
Uniprot IDs		Q9NR30	A0A024RDV7 O00505
PDB IDs		2M3D 6L5L 6L5M 6L5N 6L5O
Enriched GO Terms of Interacting Partners?
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