DDX21 and ADAMTS14

		DDX21	ADAMTS14
Description		DExD-box helicase 21	ADAM metallopeptidase with thrombospondin type 1 motif 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Mitochondrion Cytosol Membrane	Extracellular Region Extracellular Matrix
	Molecular Function	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding	Metalloendopeptidase Activity Metal Ion Binding
	Biological Process	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Defense Response To Virus R-loop Disassembly	Proteolysis Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol	Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Heel bone mineral density ( 30598549) Moderate-to-late spontaneous preterm birth ( 31194736) Optic disc size ( 31809533) Sleep duration ( 23728906) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Suicide behavior ( 26079190)
Interacting Genes		92 interacting genes: ADAMTS14 CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN KPNA3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MTHFR PIAS1 PNMA2 PTEN SGPL1 SRPK2 SUMO2 TERF1 TERF2 TET1 UBE2I	1 interacting genes: DDX21
Entrez ID		9188	140766
HPRD ID		05895	06329
Ensembl ID		ENSG00000165732	ENSG00000138316
Uniprot IDs		Q9NR30	Q8WXS8
PDB IDs		2M3D 6L5L 6L5M 6L5N 6L5O
Enriched GO Terms of Interacting Partners?
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