YTHDC1 and PLG

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		YTHDC1	PLG
Description		YTH domain containing 1	plasminogen
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Speck	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extrinsic Component Of Plasma Membrane Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	RNA Binding MRNA Binding Protein Binding N6-methyladenosine-containing RNA Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding Kinase Binding Protein Domain Specific Binding Apolipoprotein Binding Chaperone Binding Protein Antigen Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Selection MRNA Export From Nucleus Spermatogenesis Dosage Compensation By Inactivation Of X Chromosome Posttranscriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Primary Follicle Stage MRNA Alternative Polyadenylation	Proteolysis Blood Coagulation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Fibrinolysis Tissue Remodeling Biological Process Involved In Interaction With Symbiont Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Dissolution of Fibrin Clot
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic acid Aminocaproic acid Bicine Desmoteplase Aprotinin Copper Gabexate
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Obesity-related traits ( 23251661)	Aging ( 22773346) Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Childhood ear infection ( 27182965 28928442) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) End stage renal disease x APOL1 genotype interaction ( 29885931) Giant cell arteritis ( 28041642) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lp (a) levels ( 21900290) Myocardial infarction ( 26343387) Plasma plasminogen levels ( 25208887) Platelet count ( 32888494) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		42 interacting genes: ABL1 ADAMTS4 ANKRD28 CFH CLK1 CLK2 CORO1A DVL3 EDC4 EMD FYN GOLGA2 HNRNPK KHDRBS1 KHDRBS2 KHDRBS3 KRT18 KRTAP10-6 LAMC3 LAMTOR5 LZTS2 MPRIP PHF19 PICK1 PLG PROSER2 RBMY1A1 RBMY1F RBMY1J RNPS1 SDCBP2 SEPTIN10 SOX13 SRC SRPK1 SRPK2 SRSF1 SRSF2 TRA2A TRA2B TXK VPS51	61 interacting genes: ACTB AMOT ANXA2 APOH ATP5F1B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSP90AA1 HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1
Entrez ID		91746	5340
HPRD ID		11689	01417
Ensembl ID		ENSG00000083896	ENSG00000122194
Uniprot IDs		J3QR07 Q96MU7	P00747 Q5TEH5
PDB IDs		2YUD 4R3H 4R3I 6RT4 6RT5 6RT6 6RT7 6SYZ 6SZ1 6SZ2 6SZ3 6SZL 6SZN 6SZR 6SZT 6SZX 6SZY 6T01 6T02 6T03 6T04 6T05 6T06 6T07 6T08 6T09 6T0A 6T0C 6T0D 6T0O 6T0X 6T0Z 6T10 6T11 6T12 6WE8 6WE9 6WEA 6YKE 6YKI 6YKJ 6YKZ 6YL0 6YL8 6YL9 6YNI 6YNJ 6YNK 6YNL 6YNM 6YNN 6YNO 6YNP 6YOQ 6ZCM 6ZCN 6ZD9	1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4CIK 4DCB 4DUR 4DUU 5HPG 5UGD 5UGG 6D3X 6D3Y 6D3Z 6D40 6OG4 6OQJ 6OQK 6Q1U 6UZ4 6UZ5
Enriched GO Terms of Interacting Partners?
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