LRSAM1 and GRIK5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		LRSAM1	GRIK5
Description		leucine rich repeat and sterile alpha motif containing 1	glutamate ionotropic receptor kainate type subunit 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleoplasm Endoplasmic Reticulum Plasma Membrane Dendrite Kainate Selective Glutamate Receptor Complex Terminal Bouton Perikaryon Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity SH3 Domain Binding PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Polyubiquitination Autophagy Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly	Protein Retention In ER Lumen Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission Establishment Of Localization In Cell Excitatory Postsynaptic Potential Cellular Response To Glucose Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Activation of Ca-permeable Kainate Receptor
Drugs			Glutamic acid Butabarbital Topiramate
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Bipolar disorder ( 21771265) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte counts ( 32888494) Meat-related diet ( 32066663)
Interacting Genes		45 interacting genes: ATXN1 ATXN7 C5 CCDC6 DMAP1 FAM178B FXR1 GABARAPL2 GPR108 GRIK5 GSK3A KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSC1 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4	8 interacting genes: DLG4 GOLM1 GPAA1 GRID2 GRIK2 GRIK3 LRSAM1 MLF1
Entrez ID		90678	2901
HPRD ID		14325	02614
Ensembl ID		ENSG00000148356	ENSG00000105737
Uniprot IDs		A0A024R870 Q6UWE0	Q16478
PDB IDs
Enriched GO Terms of Interacting Partners?
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