GRIK5 and GRIK3

Number of citations of the paper that reports this interaction (PubMedID 9466455)
16

Data Source:
HPRD (in vivo)

		GRIK5	GRIK3
Description		glutamate ionotropic receptor kainate type subunit 5	glutamate ionotropic receptor kainate type subunit 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Plasma Membrane Dendrite Kainate Selective Glutamate Receptor Complex Terminal Bouton Perikaryon Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity SH3 Domain Binding PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Ionotropic Glutamate Receptor Activity Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Ligand-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Retention In ER Lumen Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission Establishment Of Localization In Cell Excitatory Postsynaptic Potential Cellular Response To Glucose Stimulus	Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential
Pathways		Activation of Ca-permeable Kainate Receptor	Activation of Ca-permeable Kainate Receptor Presynaptic function of Kainate receptors
Drugs		Glutamic acid Butabarbital Topiramate	Glutamic acid Butabarbital Topiramate
Diseases
GWAS		Bipolar disorder ( 21771265) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte counts ( 32888494) Meat-related diet ( 32066663)	Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Forced expiratory volume in 1 second (environmental tobacco smoke interaction) ( 28738859) Iron status biomarkers (total iron binding capacity) ( 28334935) Metabolite levels ( 23823483) Neuroticism ( 27067015) Post bronchodilator FEV1/FVC ratio ( 26634245) Schizophrenia ( 23894747)
Interacting Genes		8 interacting genes: DLG4 GOLM1 GPAA1 GRID2 GRIK2 GRIK3 LRSAM1 MLF1	2 interacting genes: FLNA GRIK5
Entrez ID		2901	2899
HPRD ID		02614	00691
Ensembl ID		ENSG00000105737	ENSG00000163873
Uniprot IDs		Q16478	Q13003
PDB IDs
Enriched GO Terms of Interacting Partners?
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