CCNT2 and HEXIM1

Number of citations of the paper that reports this interaction (PubMedID 12832472)
121

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		CCNT2	HEXIM1
Description		cyclin T2	HEXIM P-TEFb complex subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Cyclin/CDK Positive Transcription Elongation Factor Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle 7SK SnRNP
	Molecular Function	Transcription Coactivator Binding Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding P-TEFb Complex Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Cycle Skeletal Muscle Tissue Development Early Viral Transcription Late Viral Transcription Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Heart Development Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Diisocyanate-induced asthma ( 25918132) Parkinson's disease ( 28892059) Waist-to-hip ratio adjusted for BMI ( 28552196) Walking pace ( 33128006)	Asthma ( 31959851 31619474) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Insomnia ( 32332799) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		7 interacting genes: AKT3 BRD4 CDK9 HEXIM1 PKN1 RB1 SUPT5H	11 interacting genes: CCNT1 CCNT2 CDK9 EGFR ESR1 HEXIM2 RELA RN7SK TERF1 TERF2 UBE2O
Entrez ID		905	10614
HPRD ID		04839	09544
Ensembl ID		ENSG00000082258	ENSG00000186834
Uniprot IDs		B4DH21 O60583	O94992
PDB IDs		2IVX	2GD7 3S9G
Enriched GO Terms of Interacting Partners?
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