HEXIM1 and CCNT1

Number of citations of the paper that reports this interaction (PubMedID 12832472)
121

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		HEXIM1	CCNT1
Description		HEXIM P-TEFb complex subunit 1	cyclin T1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle 7SK SnRNP	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding P-TEFb Complex Binding	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Heart Development Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation By Host Of Viral Transcription Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Division Negative Regulation Of MRNA Polyadenylation
Pathways			Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Asthma ( 31959851 31619474) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Insomnia ( 32332799) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		11 interacting genes: CCNT1 CCNT2 CDK9 EGFR ESR1 HEXIM2 RELA RN7SK TERF1 TERF2 UBE2O	26 interacting genes: AFF4 AHR BRD4 CDK9 CEBPB ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2 SUPT5H
Entrez ID		10614	904
HPRD ID		09544	03938
Ensembl ID		ENSG00000186834	ENSG00000129315
Uniprot IDs		O94992	A8K4M5 O60563
PDB IDs		2GD7 3S9G	2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6Z45
Enriched GO Terms of Interacting Partners?
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