UBE2M and RNF7

Number of citations of the paper that reports this interaction (PubMedID 19250909)
117

Data Source:
BioGRID (pull down)

		UBE2M	RNF7
Description		ubiquitin conjugating enzyme E2 M	ring finger protein 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity	Copper Ion Binding Protein Binding Zinc Ion Binding NEDD8 Transferase Activity Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding
	Biological Process	Cellular Protein Modification Process Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Post-translational Protein Modification Protein Neddylation Response To Redox State
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Hepatitis C induced liver fibrosis ( 22841784) Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		32 interacting genes: APP CAND1 CBL CFL1 CPNE1 CPNE2 CPNE4 CUL1 CUL4A CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3	41 interacting genes: APOBEC3F APOBEC3G ASB11 BTRC CASP7 CBFB CDC34 CHFR CREBBP CSNK2A1 CSNK2B CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CYCS ELOB ELOC ERBIN GEM GHR GLMN IKBKG ITM2C MKRN3 MNAT1 NEDD4 NEDD4L PLA2G15 PMAIP1 SOCS3 TRIM46 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2L3 UBE2M UBE2Q1
Entrez ID		9040	9616
HPRD ID		04414	04840
Ensembl ID		ENSG00000130725	ENSG00000114125
Uniprot IDs		A0A024R4T4 P61081	Q9UBF6
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O	2ECL
Enriched GO Terms of Interacting Partners?
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