UBA3 and NEDD8

Number of citations of the paper that reports this interaction (PubMedID 10207026)
84

Data Source:
HPRD (in vivo, in vitro)

		UBA3	NEDD8
Description		ubiquitin like modifier activating enzyme 3	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Nuclear Receptor Binding NEDD8 Activating Enzyme Activity NEDD8 Transferase Activity Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Endomitotic Cell Cycle Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Neddylation
Pathways		Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Meat-related diet ( 32066663)	Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		13 interacting genes: CHD3 CPNE2 DUSP23 IMPA2 KDM1A NAE1 NEDD8 OGT TRIM55 TRIM63 UBE2D2 UBE2F UBE2M	43 interacting genes: AHR ARIH2 ATE1 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A HSPA4 N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		9039	4738
HPRD ID		04413	04412
Ensembl ID		ENSG00000144744	ENSG00000129559
Uniprot IDs		Q8TBC4	Q15843
PDB IDs		1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN 5JJM	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N
Enriched GO Terms of Interacting Partners?
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