NEDD8 and NAE1

Number of citations of the paper that reports this interaction (PubMedID 21145461)
158

Data Source:
BioGRID (x-ray crystallography, affinity chromatography technology)
HPRD (in vivo)

		NEDD8	NAE1
Description		NEDD8 ubiquitin like modifier	NEDD8 activating enzyme E1 subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Neddylation	Signal Transduction Protein Modification By Small Protein Conjugation Mitotic DNA Replication Checkpoint Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Protein Neddylation Neuron Apoptotic Process
Pathways		TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport	Neddylation
Drugs			ATP
Diseases
GWAS		Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		43 interacting genes: AHR ARIH2 ATE1 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A HSPA4 N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2	11 interacting genes: ALG8 APP GARS1 NEDD8 OGT SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4
Entrez ID		4738	8883
HPRD ID		04412	04545
Ensembl ID		ENSG00000129559	ENSG00000159593
Uniprot IDs		Q15843	Q13564
PDB IDs		1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N	1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?
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