HIP1R and PRICKLE1

		HIP1R	PRICKLE1
Description		huntingtin interacting protein 1 related	prickle planar cell polarity protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Postsynaptic Density Apical Plasma Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Ruffle Membrane Dendrite Cytoplasm Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Synaptic Membrane	Nucleus Cytosol Nuclear Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding SH3 Domain Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Zinc Ion Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly Protein Stabilization Digestive System Development Regulation Of Gastric Acid Secretion Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aorta Development Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Coronary Vasculature Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Body mass index ( 29273807) Body shape index ( 34021172) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Parkinson's disease ( 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 30285260) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		17 interacting genes: ACTA1 ACTB CIT CLTA CLTB CLTC CTTN DYNLL1 EPN1 HIP1 HTT MVK NEK1 PRICKLE1 PTPN11 TFIP11 TRIM27	14 interacting genes: ANO6 ARID2 BYSL CECR2 HIP1R JRK KIF9 LRRK2 PPP3CB PRPF31 SMURF2 TYR UTP14C VIP
Entrez ID		9026	144165
HPRD ID		10412	16341
Ensembl ID		ENSG00000130787	ENSG00000139174
Uniprot IDs		B3KQW8 B4DPL0 O75146	A0A024R0W7 B3KVG3 B3KVG6 Q96MT3
PDB IDs		1R0D
Enriched GO Terms of Interacting Partners?
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