HIP1R and CIT

		HIP1R	CIT
Description		huntingtin interacting protein 1 related	citron rho-interacting serine/threonine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Postsynaptic Density Apical Plasma Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Ruffle Membrane Dendrite Cytoplasm Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Synaptic Membrane	Cytoplasm Cytosol Cytoskeleton Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding SH3 Domain Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Endocytosis Receptor-mediated Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly Protein Stabilization Digestive System Development Regulation Of Gastric Acid Secretion Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Generation Of Neurons Neuron Apoptotic Process
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Body mass index ( 29273807) Body shape index ( 34021172) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Parkinson's disease ( 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 30285260) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Mitochondrial heteroplasmy measurement ( 33731350) Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)
Interacting Genes		17 interacting genes: ACTA1 ACTB CIT CLTA CLTB CLTC CTTN DYNLL1 EPN1 HIP1 HTT MVK NEK1 PRICKLE1 PTPN11 TFIP11 TRIM27	16 interacting genes: ABCB9 DERA DISC1 DLG4 ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG
Entrez ID		9026	11113
HPRD ID		10412	09289
Ensembl ID		ENSG00000130787	ENSG00000122966
Uniprot IDs		B3KQW8 B4DPL0 O75146	O14578
PDB IDs		1R0D
Enriched GO Terms of Interacting Partners?
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