UCN2 and CRHR2

Number of citations of the paper that reports this interaction (PubMedID 11416224)
231

Data Source:
HPRD (in vivo, in vitro)

		UCN2	CRHR2
Description		urocortin 2	corticotropin releasing hormone receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Axon Terminus
	Molecular Function	Hormone Activity Hormone Binding Corticotropin-releasing Hormone Receptor Binding Corticotropin-releasing Hormone Receptor 2 Binding	Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Digestion Hormone-mediated Signaling Pathway Cellular Response To Nutrient Levels	Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Class B/2 (Secretin family receptors)	G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)	Type 2 diabetes ( 24509480 30297969)
Interacting Genes		2 interacting genes: CRHR2 IL10RB	8 interacting genes: APP CRH GCC1 GPR35 MALL UCN UCN2 UCN3
Entrez ID		90226	1395
HPRD ID		16171	03614
Ensembl ID		ENSG00000145040	ENSG00000106113
Uniprot IDs		Q96RP3	A0A090N7T4 Q13324
PDB IDs		2RMG 3N95	3N93 3N95 3N96 6PB1
Enriched GO Terms of Interacting Partners?
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