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CCNE1 and NBN
Number of citations of the paper that reports this interaction (PubMedID
12607005
)
332
Data Source:
HPRD
(in vitro)
CCNE1
NBN
Description
cyclin E1
nibrin
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cyclin E1-CDK2 Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Nucleolus
Cytosol
PML Body
Mre11 Complex
Site Of Double-strand Break
Nuclear Inclusion Body
Molecular Function
Protein Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Damaged DNA Binding
Protein Binding
Protein N-terminus Binding
DNA-binding Transcription Factor Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
DNA Replication Initiation
Protein Phosphorylation
Homologous Chromosome Pairing At Meiosis
Wnt Signaling Pathway
Mitotic Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Regulation Of Cellular Protein Localization
DNA Damage Checkpoint Signaling
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Blastocyst Growth
Double-strand Break Repair
Mitotic G2 DNA Damage Checkpoint Signaling
Cell Population Proliferation
Regulation Of DNA-dependent DNA Replication Initiation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Telomeric 3' Overhang Formation
Positive Regulation Of Protein Autophosphorylation
Positive Regulation Of Telomere Maintenance
DNA Duplex Unwinding
Positive Regulation Of Kinase Activity
Isotype Switching
Neuromuscular Process Controlling Balance
Meiotic Cell Cycle
Regulation Of Cell Cycle
T-circle Formation
Telomere Maintenance Via Telomere Trimming
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Telomere Capping
Pathways
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
Association of TriC/CCT with target proteins during biosynthesis
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
PTK6 Regulates Cell Cycle
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
RHOBTB3 ATPase cycle
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Bladder cancer (
24163127
20972438
)
Body mass index (
25673413
)
Breast cancer (
29058716
)
Breast cancer (estrogen-receptor negative) (
29058716
)
Diastolic blood pressure (
28135244
27841878
)
Medication use (diuretics) (
31015401
)
Response to fenofibrate (total cholesterol levels) (
27002377
)
Spatial processing (
31596458
)
Walking pace (
33128006
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Interacting Genes
71 interacting genes:
AKT1
AR
ARHGEF5
ARID4A
ARIH1
ARNT
AURKA
BRCA2
BTRC
CABLES1
CALM1
CCND2
CCT4
CDC25A
CDC6
CDK1
CDK2
CDK3
CDK4
CDK6
CDKN1A
CDKN1B
CDKN2A
CDKN2B
CDKN2C
COIL
CUL3
FBXW7
FGFR4
FOXM1
FZR1
GLIS2
GMNC
GRM1
GSK3B
H1-0
H1-1
H1-5
HERC5
KAT2A
LATS2
MARCKS
MCM3
MEGF8
MRE11
MYBL2
MYC
NBN
NF2
PIN1
POLD1
PRC1
PRKAR1A
PTPA
RASSF1
RB1
RBL1
RBL2
REL
RHOBTB3
RRN3
SKP2
SMARCA4
SMARCC1
SMARCD3
SPOP
STK11
TERT
TP73
TSC1
UBTF
35 interacting genes:
ATF2
ATM
ATR
BAP1
BRCA1
CASC3
CCNE1
CDK9
CHEK2
DCLRE1C
EP300
FANCD2
H2AX
H3-4
HIF1A
MDC1
MRE11
NAT2
NCL
PRKDC
RAD18
RAD50
RAD51
RECQL5
SIRT1
SNAI1
SUMO2
TERF1
TLK1
TREX1
UBE2D1
UBE2N
VRK1
XRCC4
XRCC5
Entrez ID
898
4683
HPRD ID
00455
04050
Ensembl ID
ENSG00000105173
ENSG00000104320
Uniprot IDs
A0A0G3DHS8
P24864
V5W5X2
A0A0C4DG07
O60934
PDB IDs
1W98
5L2W
5WQD
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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