NBN and BAP1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		NBN	BAP1
Description		nibrin	BRCA1 associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body	Nucleus Nucleoplasm Cytoplasm Cytosol PR-DUB Complex
	Molecular Function	Damaged DNA Binding Protein Binding Protein N-terminus Binding DNA-binding Transcription Factor Binding	Chromatin Binding Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity
	Biological Process	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Blastocyst Growth Double-strand Break Repair Mitotic G2 DNA Damage Checkpoint Signaling Cell Population Proliferation Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Kinase Activity Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Regulation Of Cell Cycle T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Telomere Capping	Regulation Of Cell Growth Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Response To Inorganic Substance Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Negative Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Regulation Of Cell Cycle Macrophage Homeostasis Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NAT2 NCL PRKDC RAD18 RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5	30 interacting genes: BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 IGF1R ITPR3 KLF5 LINC00598 MAP3K1 NBN PARP3 PLN PTPRJ RB1CC1 STK11 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1
Entrez ID		4683	8314
HPRD ID		04050	04366
Ensembl ID		ENSG00000104320	ENSG00000163930
Uniprot IDs		A0A0C4DG07 O60934	A0A024R305 F8W6N3 Q92560
PDB IDs		5WQD
Enriched GO Terms of Interacting Partners?
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