ARF6 and EXOC5

Number of citations of the paper that reports this interaction (PubMedID 14662749)
90

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ARF6	EXOC5
Description		ADP ribosylation factor 6	exocyst complex component 5
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Membrane Endocytic Vesicle Filopodium Membrane Early Endosome Membrane Cleavage Furrow Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Glutamatergic Synapse	Exocyst Cytoplasm Cytosol Midbody
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Thioesterase Binding Protein N-terminus Binding	Protein Binding Small GTPase Binding Protein N-terminus Binding
	Biological Process	Liver Development Intracellular Protein Transport Cell Cycle Cell Adhesion Nervous System Development Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Myeloid Cell Apoptotic Process Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Establishment Of Planar Polarity Exocytosis Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Protein Transport Protein Localization To Plasma Membrane Epithelial Cell Apoptotic Process Non-motile Cilium Assembly
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)	Alcohol consumption ( 23743675) Chronotype ( 30696823) HDL cholesterol levels in HIV infection ( 33109212) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)
Interacting Genes		43 interacting genes: AGAP1 ALDH5A1 AP1B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CYTH1 CYTH2 EXOC5 EZR HTR2A IKBKG ITSN1 LSM7 MEOX2 MGAM MT2A PALS1 PIP5K1A PIP5K1C PLD1 PRPF39 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 RPLP1 SMAP1 SMARCC2 SPAG9 TOGARAM1 ZNF709	46 interacting genes: ACTR3B ADCK1 ARF6 BARD1 BRMS1L C1orf216 CCDC102B CDH2 CREBBP CRYBB1 DEUP1 DNAAF4 EDRF1 ENO2 EXOC6 EXOC6B FGA FRMD6 GNB1 HDDC3 HGS ICA1 IFT57 KIAA0586 KIFC3 KXD1 MAGEA3 MAGEA6 OAS1 PRKCG PSTPIP1 PTK6 PYCARD RAB14 RAB4A RAB4B RALA SOX10 SPACA9 TBX21 THOC1 TNPO2 TTC23L TXLNB TXNL4A USP2
Entrez ID		382	10640
HPRD ID		02714	07258
Ensembl ID		ENSG00000165527	ENSG00000070367
Uniprot IDs		P62330	O00471
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU
Enriched GO Terms of Interacting Partners?
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