TOP3B and CHD8

Number of citations of the paper that reports this interaction (PubMedID 11549288)
5

Data Source:
HPRD (two hybrid)

		TOP3B	CHD8
Description		DNA topoisomerase III beta	chromodomain helicase DNA binding protein 8
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus	Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex
	Molecular Function	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	DNA Topological Change Chromosome Segregation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Remodeling Brain Development Wnt Signaling Pathway DNA Duplex Unwinding Social Behavior Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process
Pathways			Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)	Height ( 31562340) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		24 interacting genes: ADAMTSL4 AXIN2 BHLHB9 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF250 ZNF408	11 interacting genes: AR ASH2L CHD7 CREB1 CTCF CTNNB1 RBBP5 RCHY1 SUMO2 TOP3B WDR5
Entrez ID		8940	57680
HPRD ID		04662	16712
Ensembl ID		ENSG00000100038	ENSG00000100888
Uniprot IDs		A0A024R1C2 A8K4N2 O95985	Q9HCK8
PDB IDs		5GVC 5GVE	2CKA 2DL6
Enriched GO Terms of Interacting Partners?
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