TIMELESS and TF

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TIMELESS	TF
Description		timeless circadian regulator	transferrin
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Replication Fork Protection Complex Site Of Double-strand Break	Extracellular Region Extracellular Space Early Endosome Late Endosome Endoplasmic Reticulum Lumen Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Extrinsic Component Of External Side Of Plasma Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex
	Molecular Function	DNA Binding Protein Binding	Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity Transferrin Receptor Binding
	Biological Process	DNA Replication Checkpoint Signaling Morphogenesis Of An Epithelium DNA Repair Cellular Response To DNA Damage Stimulus Circadian Rhythm Detection Of Abiotic Stimulus Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Replication Fork Protection Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair	Retina Homeostasis Iron Ion Transport Cellular Iron Ion Homeostasis Actin Filament Organization Antibacterial Humoral Response Osteoclast Differentiation Regulation Of Protein Stability Regulation Of Iron Ion Transport Positive Regulation Of Phosphorylation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor-mediated Endocytosis Iron Ion Homeostasis SMAD Protein Signal Transduction ERK1 And ERK2 Cascade Cellular Response To Iron Ion Positive Regulation Of Cell Motility
Pathways		Processing of DNA double-strand break ends	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling
Drugs			Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Dichlorvos Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)	Alcohol consumption (transferrin glycosylation) ( 21665994) HDL cholesterol levels ( 32203549) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 25224454 21483845 21208937 19084217) Iron status biomarkers (iron levels) ( 28334935 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 33536631 25352340) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252)
Interacting Genes		9 interacting genes: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1	42 interacting genes: AQP9 CALR CANX CLDN5 CPLX4 CUBN DRD2 ELOVL4 ERGIC3 FAM210B GJB1 GOLM1 GPR42 GPX8 GRB2 HSD17B13 HSP90AA1 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 LEUTX PGRMC2 RMDN3 SH3BP2 SLC10A6 SLC26A6 SMAD3 SORT1 SPINT1 SYT2 TFR2 TFRC TIMELESS TMEM52B TUBB3 VKORC1
Entrez ID		8914	7018
HPRD ID		04864	01811
Ensembl ID		ENSG00000111602	ENSG00000091513
Uniprot IDs		Q9UNS1	A0PJA6 P02787 Q06AH7
PDB IDs		4XHT 4XHU 4XHW 5MQI 6T9Q 6TAZ	1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6JAS 6SOY 6SOZ 6UJ6
Enriched GO Terms of Interacting Partners?
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