TIMELESS and PER1

Number of citations of the paper that reports this interaction (PubMedID 9856465)
89

Data Source:
HPRD (in vitro)

		TIMELESS	PER1
Description		timeless circadian regulator	period circadian regulator 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Replication Fork Protection Complex Site Of Double-strand Break	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Protein Binding Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding E-box Binding
	Biological Process	DNA Replication Checkpoint Signaling Morphogenesis Of An Epithelium DNA Repair Cellular Response To DNA Damage Stimulus Circadian Rhythm Detection Of Abiotic Stimulus Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Replication Fork Protection Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Sodium Ion Transport Circadian Rhythm Entrainment Of Circadian Clock Posttranscriptional Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Entrainment Of Circadian Clock By Photoperiod Histone H3 Acetylation Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Response To CAMP Histone H3 Deacetylation Circadian Regulation Of Translation Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of P38MAPK Cascade Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Processing of DNA double-strand break ends	Circadian Clock
Drugs
Diseases
GWAS		Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)	HDL cholesterol levels ( 32203549) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		9 interacting genes: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1	19 interacting genes: CCDC57 CRY1 CRY2 CSNK1D CSNK1E CSNK1G2 CSNK2B DELEC1 GPRASP1 HIF1A LTB4R2 PER2 PER3 PNMA1 RBPMS RIPOR2 TIMELESS TNS2 TRIP6
Entrez ID		8914	5187
HPRD ID		04864	03774
Ensembl ID		ENSG00000111602	ENSG00000179094
Uniprot IDs		Q9UNS1	O15534
PDB IDs		4XHT 4XHU 4XHW 5MQI 6T9Q 6TAZ	1UL6
Enriched GO Terms of Interacting Partners?
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