TRIM4 and TRPM8

Number of citations of the paper that reports this interaction (PubMedID 33037615)
1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TRIM4	TRPM8
Description		tripartite motif containing 4	transient receptor potential cation channel subfamily M member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane Raft
	Molecular Function	Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Cation Channel Activity Calcium Channel Activity Protein Binding Identical Protein Binding Ligand-gated Calcium Channel Activity
	Biological Process	Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response	Cellular Calcium Ion Homeostasis Response To Cold Detection Of Temperature Stimulus Calcium-mediated Signaling Thermoception Calcium Ion Transmembrane Transport Cation Transmembrane Transport Positive Regulation Of Cold-induced Thermogenesis
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation	TRP channels
Drugs			Levomenthol Camphor Cannabidiol (S)-camphor Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175) Estrone levels ( 29325096) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum metabolite levels ( 23093944) Tacrolimus trough concentration in kidney transplant patients ( 29160300)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 31319653) Blood pressure measurement (cold pressor test) ( 24165912) Hair greying ( 26926045) Headache ( 29397368) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 21666692 27322543) Migraine - clinic-based ( 23793025) Migraine with aura ( 23793025) Migraine without aura ( 23793025 27322543)
Interacting Genes		4 interacting genes: MDM2 SRPK2 TRIM41 TRPM8	1 interacting genes: TRIM4
Entrez ID		89122	79054
HPRD ID		15556	09454
Ensembl ID		ENSG00000146833	ENSG00000144481
Uniprot IDs		Q9C037	Q7Z2W7 W8DTH1
PDB IDs
Enriched GO Terms of Interacting Partners?
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