TRPM8 and TRIM4

Number of citations of the paper that reports this interaction (PubMedID 33037615)
1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TRPM8	TRIM4
Description		transient receptor potential cation channel subfamily M member 8	tripartite motif containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane Raft	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Cation Channel Activity Calcium Channel Activity Protein Binding Identical Protein Binding Ligand-gated Calcium Channel Activity	Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Calcium Ion Homeostasis Response To Cold Detection Of Temperature Stimulus Calcium-mediated Signaling Thermoception Calcium Ion Transmembrane Transport Cation Transmembrane Transport Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response
Pathways		TRP channels	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Levomenthol Camphor Cannabidiol (S)-camphor Tetrahydrocannabivarin Medical Cannabis Nabiximols
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 31319653) Blood pressure measurement (cold pressor test) ( 24165912) Hair greying ( 26926045) Headache ( 29397368) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 21666692 27322543) Migraine - clinic-based ( 23793025) Migraine with aura ( 23793025) Migraine without aura ( 23793025 27322543)	Dehydroepiandrosterone sulphate levels ( 21533175) Estrone levels ( 29325096) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum metabolite levels ( 23093944) Tacrolimus trough concentration in kidney transplant patients ( 29160300)
Interacting Genes		1 interacting genes: TRIM4	4 interacting genes: MDM2 SRPK2 TRIM41 TRPM8
Entrez ID		79054	89122
HPRD ID		09454	15556
Ensembl ID		ENSG00000144481	ENSG00000146833
Uniprot IDs		Q7Z2W7 W8DTH1	Q9C037
PDB IDs
Enriched GO Terms of Interacting Partners?
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