SGPL1 and FAM177A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SGPL1	FAM177A1
Description		sphingosine-1-phosphate lyase 1	family with sequence similarity 177 member A1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Pyridoxal Phosphate Binding
	Biological Process	Luteinization Vasculogenesis Kidney Development Fatty Acid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis
Drugs		Pyridoxal phosphate
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Blood protein levels ( 30072576 29875488) Circulating fibroblast growth factor 23 levels ( 30217807) Colorectal carcinoma in primary sclerosing cholangitis ( 28779025) Hip index ( 34021172) Lymphocyte counts ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		37 interacting genes: ANK3 AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 DDX21 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TRARG1 TSPAN4 UNC50	8 interacting genes: AQP6 DPM3 ELOVL4 FATE1 JAGN1 PBX3 SGPL1 TMX2
Entrez ID		8879	283635
HPRD ID		07224	12644
Ensembl ID		ENSG00000166224	ENSG00000151327
Uniprot IDs		O95470	Q8N128
PDB IDs		4Q6R
Enriched GO Terms of Interacting Partners?
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