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FADD and IRAK1
Number of citations of the paper that reports this interaction (PubMedID
11828002
)
19
Data Source:
HPRD
(in vitro)
FADD
IRAK1
Description
Fas associated via death domain
interleukin 1 receptor associated kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Neuron Projection
Cell Body
Membrane Raft
Ripoptosome
Nucleus
Nucleoplasm
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Endosome Membrane
Protein-containing Complex
Molecular Function
Protease Binding
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Tumor Necrosis Factor Receptor Superfamily Binding
Receptor Serine/threonine Kinase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Caspase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Biological Process
Kidney Development
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Adaptive Immune Response
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
T Cell Differentiation In Thymus
TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Morphine
Innate Immune Response
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Cocaine
Lymph Node Development
Spleen Development
Thymus Development
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Necroptotic Process
Negative Regulation Of Activation-induced Cell Death Of T Cells
Cellular Response To Mechanical Stimulus
Death-inducing Signaling Complex Assembly
Motor Neuron Apoptotic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of Cysteine-type Endopeptidase Activity
Necroptotic Signaling Pathway
Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Activation Of NF-kappaB-inducing Kinase Activity
JNK Cascade
Aging
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways
Caspase activation via Death Receptors in the presence of ligand
TRIF-mediated programmed cell death
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Defective RIPK1-mediated regulated necrosis
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Transcriptional Regulation by MECP2
Interleukin-1 signaling
IRAK1 recruits IKK complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Fostamatinib
Diseases
GWAS
Diverticular disease (
30177863
)
Celiac disease (
22057235
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Rheumatoid arthritis (
32723749
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Systemic lupus erythematosus (
26606652
33272962
26663301
26502338
19838195
)
Interacting Genes
54 interacting genes:
ABCA1
ANK3
ATG5
BTG1
CASP10
CASP8
CASP8AP2
CFLAR
CSNK1A1
DAP3
DAPK1
DDIT4L
DDX24
DEDD
EDA2R
FAF1
FAS
FASLG
HIPK3
IKBKG
IRAK1
LRRCC1
MBD4
MKRN1
MOB4
MYD88
NACA
NOL3
NUTM2F
PARK7
PEA15
PIDD1
PIN1
PRKCZ
PTPN13
RALBP1
RAP1A
RIPK1
RNF4
RYBP
SDCBP
STAT1
STUB1
TAB1
TCEA2
TNFRSF10A
TNFRSF10B
TRADD
TRAF2
TRIM21
UBE2I
XPO5
ZCCHC12
ZMYM5
59 interacting genes:
AKT1
BCL10
BTK
CCDC47
FADD
GDI1
H3-4
HRAS
HSP90AA1
IDS
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JADE2
JUN
LDHD
MAGEA2
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NMRK2
NTRK3
OPTN
PELI1
PELI2
PELI3
PPP3CB
PRKCI
PRKCZ
RAB31
RASSF2
RIPK2
RPF1
SIGIRR
SQSTM1
STAT3
STING1
SUMO1
TAB2
TICAM2
TIFA
TIRAP
TLR2
TLR4
TOLLIP
TRAF4
TRAF6
TRIM32
UBE2E3
YTHDC2
Entrez ID
8772
3654
HPRD ID
03909
02235
Ensembl ID
ENSG00000168040
ENSG00000184216
Uniprot IDs
Q13158
D3YTB5
P51617
PDB IDs
1A1W
1A1Z
1E3Y
1E41
2GF5
3EZQ
3OQ9
6ACI
6BFN
Enriched GO Terms of Interacting Partners
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