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IRAK1 and TRIM32
Number of citations of the paper that reports this interaction (PubMedID
21903422
)
143
Data Source:
BioGRID
(affinity chromatography technology, pull down)
IRAK1
TRIM32
Description
interleukin 1 receptor associated kinase 1
tripartite motif containing 32
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Endosome Membrane
Protein-containing Complex
Nucleus
Cytoplasm
Cytosol
Striated Muscle Myosin Thick Filament
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Myosin Binding
Tat Protein Binding
Translation Initiation Factor Binding
Identical Protein Binding
Ubiquitin Binding
Protein Self-association
Ubiquitin Protein Ligase Activity
Biological Process
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Activation Of NF-kappaB-inducing Kinase Activity
JNK Cascade
Aging
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Protein Polyubiquitination
Tissue Homeostasis
Ubiquitin-dependent Protein Catabolic Process
Actin Ubiquitination
Response To UV
Protein Ubiquitination
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Viral Transcription
Response To Tumor Necrosis Factor
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Fat Cell Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Cycle
Positive Regulation Of Proteolysis
Positive Regulation Of Transcription, DNA-templated
Muscle Cell Cellular Homeostasis
Negative Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Striated Muscle Cell Differentiation
Axon Development
Protein K48-linked Ubiquitination
Negative Regulation Of Viral Release From Host Cell
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production
Positive Regulation Of Cell Motility
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Transcriptional Regulation by MECP2
Interleukin-1 signaling
IRAK1 recruits IKK complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Regulation of innate immune responses to cytosolic DNA
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Fostamatinib
Diseases
GWAS
Celiac disease (
22057235
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Rheumatoid arthritis (
32723749
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Systemic lupus erythematosus (
26606652
33272962
26663301
26502338
19838195
)
Estimated glomerular filtration rate (
31015462
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
59 interacting genes:
AKT1
BCL10
BTK
CCDC47
FADD
GDI1
H3-4
HRAS
HSP90AA1
IDS
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JADE2
JUN
LDHD
MAGEA2
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NMRK2
NTRK3
OPTN
PELI1
PELI2
PELI3
PPP3CB
PRKCI
PRKCZ
RAB31
RASSF2
RIPK2
RPF1
SIGIRR
SQSTM1
STAT3
STING1
SUMO1
TAB2
TICAM2
TIFA
TIRAP
TLR2
TLR4
TOLLIP
TRAF4
TRAF6
TRIM32
UBE2E3
YTHDC2
70 interacting genes:
ABI2
AKTIP
APOL1
ASIC4
ASTN2
ATP2B1
ATXN1
CLIP4
DERL1
ERGIC3
FADS6
GABARAP
GABARAPL1
GABARAPL2
GEM
GLIS2
GPR137B
GSN
HSPA4
ICMT
IQCB1
IRAK1
KCTD9
LCN2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MID2
MOB1A
MYCN
NDRG2
NPAS3
NTAQ1
PDE9A
PELI2
PIAS3
PIAS4
POLE3
PTCD2
PTPN11
RAB29
RABAC1
RNF208
RNF41
SCGB1A1
SDCBP
STING1
SYT6
TCEANC
TNC
TOP1
TRIM23
TRIM27
TRIM5
TRIM72
TTC23
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBE2V1
UBQLN1
UBQLN4
VPS11
XIAP
Entrez ID
3654
22954
HPRD ID
02235
03797
Ensembl ID
ENSG00000184216
ENSG00000119401
Uniprot IDs
D3YTB5
P51617
A0A024R843
Q13049
PDB IDs
6BFN
2CT2
5FEY
Enriched GO Terms of Interacting Partners
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