SNX4 and SNX6

Number of citations of the paper that reports this interaction (PubMedID 11279102)
47

Data Source:
HPRD (in vitro, in vivo)

		SNX4	SNX6
Description		sorting nexin 4	sorting nexin 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoplasmic Dynein Complex Plasma Membrane Membrane SNARE Complex Early Endosome Membrane Protein-containing Complex	Nucleus Cytoplasm Endosome Cytosol Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Tubular Endosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Protein Binding Dynactin Binding Type I Transforming Growth Factor Beta Receptor Binding Phosphatidylinositol Binding Protein Homodimerization Activity
	Biological Process	Protein Transport Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell	Intracellular Protein Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Macroautophagy Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Histamine Secretion By Mast Cell Cellular Response To Amyloid-beta
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder x sex interaction ( 34099189) Urate levels ( 31578528)	Atrial fibrillation ( 29892015) Celiac disease ( 23936387) Diastolic blood pressure ( 30224653) Normal facial asymmetry (angle of surface orientation score) ( 30631343)
Interacting Genes		19 interacting genes: AGK ARL6IP1 ATP6V0A1 BIN1 DGAT2L6 EGFR HIVEP1 INSR LEPR MAGEA6 OGT PDGFRA PDGFRB PTPN5 SH3GLB1 SNX2 SNX6 SNX7 SUPT5H	27 interacting genes: ACVR2B ACVRL1 BMPR1B BRCA1 BRMS1 CALM1 COIL CSNK2A2 DISC1 EGFR ESR1 INSR LEPR NDEL1 OGT OPTN PDGFRA PIM1 RAG1 SNX1 SNX2 SNX4 TEX11 TGFBR1 TGFBR2 TNIK TPT1
Entrez ID		8723	58533
HPRD ID		09334	12086
Ensembl ID		ENSG00000114520	ENSG00000129515
Uniprot IDs		O95219	A0A0A0MRI2 Q9UNH7
PDB IDs
Enriched GO Terms of Interacting Partners?
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