PNPT1 and WDPCP

		PNPT1	WDPCP
Description		polyribonucleotide nucleotidyltransferase 1	WD repeat containing planar cell polarity effector
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Polysomal Ribosome Mitochondrial Degradosome	Plasma Membrane Axoneme Cell Cortex Apical Plasma Membrane Axonemal Basal Plate
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Polyribonucleotide Nucleotidyltransferase Activity Protein Binding Poly(U) RNA Binding Poly(G) Binding MiRNA Binding
	Biological Process	Mitochondrial RNA Catabolic Process Mitochondrial MRNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial RNA 5'-end Processing Mitochondrial RNA 3'-end Processing RNA Catabolic Process MRNA Catabolic Process Cellular Response To Oxidative Stress Cellular Response To Interferon-beta RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Regulation Of Cellular Respiration RNA Polyadenylation Negative Regulation Of Growth Protein Homooligomerization Response To CAMP Regulation Of Cell Cycle Response To Growth Hormone Positive Regulation Of MRNA Catabolic Process Protein Homotrimerization Mitochondrion Morphogenesis Nuclear Polyadenylation-dependent MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Mitochondrial MRNA Polyadenylation Liver Regeneration Positive Regulation Of MiRNA Catabolic Process Regulation Of Cellular Senescence	Kidney Development Auditory Receptor Cell Morphogenesis Smoothened Signaling Pathway Nervous System Development Regulation Of Fibroblast Migration Regulation Of Embryonic Cell Shape Septin Cytoskeleton Organization Regulation Of Protein Localization Embryonic Digit Morphogenesis Camera-type Eye Development Tongue Morphogenesis Cilium Organization Establishment Of Protein Localization Regulation Of Focal Adhesion Assembly Digestive System Development Roof Of Mouth Development Cilium Assembly Respiratory System Development Circulatory System Development Glomerular Visceral Epithelial Cell Migration Regulation Of Ruffle Assembly Regulation Of Establishment Of Cell Polarity
Pathways
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diastolic blood pressure ( 27618452) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Height ( 28552196 25429064 18391951) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998 31959993) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Optic cup area ( 28073927) Pulse pressure ( 28135244 27841878) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618452) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Academic attainment (English) ( 33594131) Anxiety ( 33859377) Asthma and attention deficit hyperactivity disorder ( 31619474) Childhood ear infection ( 27182965) Cutaneous malignant melanoma ( 26237428) Depression ( 33859377) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Prostate cancer ( 31562322) Regular attendance at a religious group ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		4 interacting genes: ADARB1 C2orf74 HSPB1 WDPCP	9 interacting genes: AHSA2P B3GNT2 CCT4 COMMD1 EHBP1 FAM161A PNPT1 PPP3R1 USP34
Entrez ID		87178	51057
HPRD ID		18493	14228
Ensembl ID		ENSG00000138035	ENSG00000143951
Uniprot IDs		Q8TCS8	O95876
PDB IDs		3U1K 5ZF6
Enriched GO Terms of Interacting Partners?
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