PNPT1 and ADARB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PNPT1	ADARB1
Description		polyribonucleotide nucleotidyltransferase 1	adenosine deaminase RNA specific B1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Membrane Cytosol Polysomal Ribosome Mitochondrial Degradosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Polyribonucleotide Nucleotidyltransferase Activity Protein Binding Poly(U) RNA Binding Poly(G) Binding MiRNA Binding	RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity MRNA Binding Protein Binding TRNA-specific Adenosine Deaminase Activity Metal Ion Binding
	Biological Process	Mitochondrial RNA Catabolic Process Mitochondrial MRNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial RNA 5'-end Processing Mitochondrial RNA 3'-end Processing RNA Catabolic Process MRNA Catabolic Process Cellular Response To Oxidative Stress Cellular Response To Interferon-beta RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Regulation Of Cellular Respiration RNA Polyadenylation Negative Regulation Of Growth Protein Homooligomerization Response To CAMP Regulation Of Cell Cycle Response To Growth Hormone Positive Regulation Of MRNA Catabolic Process Protein Homotrimerization Mitochondrion Morphogenesis Nuclear Polyadenylation-dependent MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Mitochondrial MRNA Polyadenylation Liver Regeneration Positive Regulation Of MiRNA Catabolic Process Regulation Of Cellular Senescence	Adenosine To Inosine Editing RNA Processing MRNA Processing Neuromuscular Synaptic Transmission Negative Regulation Of Cell Population Proliferation Base Conversion Or Substitution Editing Facial Nerve Morphogenesis Hypoglossal Nerve Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Cell Migration Multicellular Organism Growth Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Neuromuscular Process Controlling Posture Defense Response To Virus Regulation Of Cell Cycle Innervation Muscle Tissue Morphogenesis Motor Behavior Motor Neuron Apoptotic Process
Pathways			C6 deamination of adenosine Formation of editosomes by ADAR proteins
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diastolic blood pressure ( 27618452) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Height ( 28552196 25429064 18391951) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998 31959993) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Optic cup area ( 28073927) Pulse pressure ( 28135244 27841878) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618452) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 28552196 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Adult body size ( 32376654) Age at first birth ( 34211149) Body mass index ( 28892062 25673413) Gastroesophageal reflux disease ( 34187846) HDL cholesterol levels ( 32203549) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Pulmonary function ( 17903307) Triglyceride levels ( 32203549) Type 2 diabetes ( 30130595)
Interacting Genes		4 interacting genes: ADARB1 C2orf74 HSPB1 WDPCP	54 interacting genes: APP EHHADH EIF2AK2 MIR1-1 MIR1-2 MIR106A MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A2 MIR19B2 MIR200A MIR200B MIR206 MIR221 MIR222 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F1 MIRLET7F2 MIRLET7G NKRF PIN1 PNPT1 PRKRA STAU1 STOX1 STRBP TARBP2 TCEANC UBE2I ZMAT4 ZNF346
Entrez ID		87178	104
HPRD ID		18493	06777
Ensembl ID		ENSG00000138035	ENSG00000197381
Uniprot IDs		Q8TCS8	P78563
PDB IDs		3U1K 5ZF6	1ZY7 5ED1 5ED2 5HP2 5HP3 6D06 6VFF
Enriched GO Terms of Interacting Partners?
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