SERPINH1 and UBTF

Number of citations of the paper that reports this interaction (PubMedID 11106745)
49

Data Source:
HPRD (in vivo, in vitro)

		SERPINH1	UBTF
Description		serpin family H member 1	upstream binding transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Raft Collagen-containing Extracellular Matrix	Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Collagen Binding Unfolded Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding
	Biological Process	Chondrocyte Development Involved In Endochondral Bone Morphogenesis Response To Unfolded Protein Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Collagen Biosynthetic Process Protein Maturation	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway
Pathways		Collagen biosynthesis and modifying enzymes	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Body shape index ( 34021172) Coronary artery disease ( 29212778 33020668) Height ( 28552196 20881960 22021425 25282103 25429064 31562340 28270201 33713608) Hip circumference adjusted for BMI ( 34021172 25673412) Myocardial infarction ( 33532862) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) hemolysis of donated blood (osmotic) ( 34014839) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		20 interacting genes: BAG6 BRCA2 C1QL3 CD9 CDK9 CEP70 COL26A1 ESR2 FEZ1 H1-5 KLF13 LINC01554 NSG2 OGT PC PPARG SLC2A4 SLC35F6 UBQLN4 UBTF	34 interacting genes: AURKA CCNA2 CCND1 CCNE1 CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 EP300 GSK3A IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E POLR1G RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2
Entrez ID		871	7343
HPRD ID		02968	02814
Ensembl ID		ENSG00000149257	ENSG00000108312
Uniprot IDs		A0A024R5K8 A8K259 P50454	P17480
PDB IDs			1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?
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